Adderal XR - Side Effects & Drug Interactions

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The following adverse reactions have been associated with amphetamine use:

Cardiovascular:

Palpitations, tachycardia, elevation of blood pressure. There have been isolated reports of cardiomyopathy associated with chronic amphetamine use.

Central Nervous System:

Psychotic episodes at recommended doses, overstimulation, restlessness, dizziness, insomnia, euphoria, dyskinesia, dysphoria, tremor, headache, exacerbation of motor and phonic tics and Tourette's syndrome. Gastrointestinal: Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. Anorexia and weight loss may occur as undesirable effects.

Allergic:

Urticaria.

Endocrine:

Impotence, changes in libido.

Body System Preferred Term ADDERALL XRª (N= 374) Placebo (N= 210) General Abdominal Pain (stomachache) 14% 10%

Accidental Injury 3% 2%

Asthenia (fatigue) 2% 0%

Fever 5% 2%

Infection 4% 2%

Viral Infection 2% 0%

Digestive System Loss of Appetite 22% 2%

Diarrhea 2% 1%

Dyspepsia 2% 1%

Nausea 5% 3%

Vomiting 7% 4%

Nervous System Dizziness 2% 0%

Emotional Lability 9% 2%

Insomnia 17% 2%

Nervousness 6% 2%

Metabolic/ Nutritional Weight Loss 4% 0%

DRUG ABUSE AND DEPENDENCE

ADDERALL XRª is a Schedule II controlled substance. Amphetamines have been extensively abused. Tolerance, extreme psychological dependence, and severe social disability have occurred. There are reports of patients who have increased the dosage to many times that recommended.

Abrupt cessation following prolonged high dosage administration results in extreme fatigue and mental depression; changes are also noted on the sleep EEG. Manifestations of chronic intoxication with amphetamines may include severe dermatoses, marked insomnia, irritability, hyperactivity, and personality changes. The most severe manifestation of chronic intoxication is psychosis, often clinically indistinguishable from schizophrenia.

Drug Interactions:

Acidifying agents

Gastrointestinal acidifying agents (guanethidine, reserpine, glutamic acid HCI, ascorbic acid, etc.) lower absorption of amphetamines.