Advair Diskus - Indications & Dosage

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For all patients it is desirable to titrate to the lowest effective strength after adequate asthma stability is achieved.

Table 5. Recommended Dosages of ADVAIR DISKUS for Patients With Asthma Taking Inhaled Corticosteroids

Current Daily Dose of Inhaled Corticosteroid

Recommended Strength and Dosing Schedule

of ADVAIR DISKUS

Beclomethasone dipropionate 420 mcg

462-840 mcg

100/50 twice daily

250/50 twice daily

Budesonide 400 mcg 800-1,200 mcg

1,600 mcg*

100/50 twice daily

250/50 twice daily

500/50 twice daily

Flunisolide 1,000 mcg

1,250-2,000 mcg

100/50 twice daily

250/50 twice daily

Fluticasone propionate

inhalation aerosol

176 mcg

440 mcg

660-880 mcg *

100/50 twice daily

250/50 twice daily

500/50 twice daily

Fluticasone propionate

inhalation powder

200 mcg

500 mcg

1,000 mcg *

100/50 twice daily

250/50 twice daily

500/50 twice daily

Triamcinolone acetonide 1,000 mcg

1,100-1,600 mcg

100/50 twice daily

250/50 twice daily *

ADVAIR DISKUS should not be used for transferring patients from systemic corticosteroid therapy.

ADVAIR DISKUS should be administered twice daily every day. More frequent administration (more than twice daily) or a higher number of inhalations (more than 1 inhalation twice daily) of the prescribed strength of ADVAIR DISKUS is not recommended as some patients are more likely to experience adverse effects with higher doses of salmeterol. The safety and efficacy of ADVAIR DISKUS when administered in excess of recommended doses have not been established. If symptoms arise in the period between doses, an inhaled, short-acting beta2-agonist should be taken for immediate relief. Patients who are receiving ADVAIR DISKUS twice daily should not use additional salmeterol or other inhaled, long-acting beta2-agonists (e.g., formoterol) for prevention of EIB, or for any other reason.

Improvement in asthma control following inhaled administration of ADVAIR DISKUS can occur within 30 minutes of beginning treatment, although maximum benefit may not be achieved for 1 week or longer after starting treatment. Individual patients will experience a variable time to onset and degree of symptom relief.