Biaxin - Indications & Dosage

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DOSAGE AND ADMINISTRATION

BIAXIN® Filmtab® (clarithromycin tablets, USP) and BIAXIN ® Granules (clarithromycin for oral suspension, USP) may be given with or without food. BIAXIN ® XL Filmtab ® (clarithromycin extended-release tablets) should be taken with food. BIAXIN® XL Filmtab® should be swallowed whole and not chewed, broken or crushed.

ADULT DOSAGE GUIDELINES

BIAXIN Tablets BIAXIN XL Tablets

Infection Dosage Duration Dosage Duration

(q12h) (days) (q24h) (days)

Pharyngitis/Tonsillitis

due to S. pyogenes 250 mg 10 - -

Acute maxillary sinusitis due to 500 mg 14 2 x 500 mg 14

H. influenzae

M. catarrhalis

S. pneumoniae

Acute exacerbation of chronic bronchitis due to

H. influenzae 500 mg 7-14 2 x 500 mg 7

H. parainfluenzae 500 mg 7 2 x 500 mg 7

M. catarrhalis 250 mg 7-14 2 x 500 mg 7

S. pneumoniae 250 mg 7-14 2 x 500 mg 7

Community-Acquired

Pneumonia due to

H. influenzae 250 mg 7 2 x 500 mg 7

H. parainfluenzae - - 2 x 500 mg 7

M. catarrhalis - - 2 x 500 mg 7

S. pneumoniae 250 mg 7-14 2 x 500 mg 7

C. pneumoniae 250 mg 7-14 2 x 500 mg 7

M. pneumoniae 250 mg 7-14 2 x 500 mg 7

Uncomplicated skin and skin structure 250 mg 7-14 - -

S. aureus

S. pyogenes

H. pyloriEradication to Reduce the Risk of Duodenal Ulcer Recurrence

Triple therapy:

BIAXIN/lansoprazole/amoxicillin

The recommended adult dose is 500 mg BIAXIN, 30 mg lansoprazole, and 1 gram amoxicillin, all given twice daily (q12h)for 10 or 14 days. (See INDICATIONS AND USAGE and CLINICAL STUDIES sections.)

Triple therapy:

BIAXIN/omeprazole/amoxicillin

The recommended adult dose is 500 mg BIAXIN, 20 mg omeprazole, and 1 gram amoxicillin, all given twice daily (q12h) for 10 days. (See INDICATIONS AND USAGE and CLINICAL STUDIES sections.) In patients with an ulcer present at the time of initiation of therapy, an additional 18 days of omeprazole 20 mg once daily is recommended for ulcer healing and symptom relief.

Dual therapy: BIAXIN/omeprazole

The recommended adult dose is 500 mg BIAXIN given three times daily (q8h) and 40 mg omeprazole given once daily (qAM) for 14 days. (See INDICATIONS AND USAGE and CLINICAL STUDIES sections.) An additional 14 days of omeprazole 20 mg once daily is recommended for ulcer healing and symptom relief.