Cartia XT - Clinical Pharmacology

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When diltiazem hydrochloride extended-release capsule (once-a-day dosage) was coadministered with a high fat content breakfast, the extent of diltiazem absorption was not affected. Dose-dumping does not occur. The apparent elimination half-life after single or multiple dosing is 5 to 8 hours. A departure from linearity similar to that seen with diltiazem tablets and diltiazem hydrochloride capsules (twice daily) is observed.

As the dose of diltiazem hydro-chloride extended-release capsules (once-a-day dosage) is increased from a daily dose of 120 mg to 240 mg, there is an increase in the area-under-the curve of 2.7 times. When the dose is increased from 240 mg, to 360 mg there is an increase in the area-under-the-curve of 1.6 times.