Coumadin - Overdosage & Contraindications

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Hemorrhagic tendencies or blood dyscrasias.

Recent or contemplated surgery of:

(1) central nervous system;

(2) eye;

(3) traumatic surgery resulting in large open surfaces.

Bleeding tendencies associated with active ulceration or overt bleeding of: (1) gastrointestinal, genitourinary or respiratory tracts;

(2) cerebrovascular hemorrhage;

(3) aneurysms-cerebral, dissecting aorta;

(4) pericarditis and pericardial effusions;

(5) bacterial endocarditis.

Threatened abortion, eclampsia and preeclampsia.

Inadequate laboratory facilities. Unsupervised patients with senility, alcoholism, or psychosis or other lack of patient cooperation. Spinal puncture and other diagnostic or therapeutic procedures with potential for uncontrollable bleeding.

Miscellaneous:

major regional, lumbar block anesthesia, malignant hypertension and known hypersensitivity to warfarin or to any other components of this product.

OVERDOSAGE

Signs and Symptoms:

Suspected or overt abnormal bleeding (e. g., appearance of blood in stools or urine, hematuria, excessive menstrual bleeding, melena, petechiae, excessive bruising or persistent oozing from superficial injuries) are early manifestations of anticoagulation beyond a safe and satisfactory level.

Treatment:

Excessive anticoagulation, with or without bleeding, may be controlled by discontinuing COUMADIN therapy and if necessary, by administration of oral or parenteral vitamin K

1 . (Please see recommendations accom-panying vitamin K 1 preparations prior to use.)

Bladder Wrack (Fucus) Pau d'arco

Miscellaneous botanticals with anticoagulant properties:

edema hereditary coumarin resistance

hyperlipemia

hypothyroidism nephrotic syndrome

Classes of Drugs

Adrenal Cortical Steroid Inhibitors Antacids

Antianxiety Agents Antiarrhythmics *

Antibiotics * Anticonvulsants *

Antidepressants * Antihistamines

Antineoplastics * Antipsychotic Medications

Antithyroid Drugs * Barbiturates

Diuretics * Enteral Nutritional Supplements

Fungal Medications, Systemic * Gastric Acidity and

Peptic Ulcer Agents * Hypnotics *