Coumadin - Overdosage & Contraindications

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Hypolipidemics * Bile Acid-Binding Resins *

HMG-CoA Reductase Inhibitors * Immunosuppressives

Oral Contraceptives, Estrogen Containing

Selective Estrogen Receptor Modulators

Steroids, Adrenocortical * Tuberculosis Agents *

Vitamins *

Specific Drugs Reported

alcohol * aminoglutethimide

amobarbital atorvastatin *

azathioprine butabarbital

butalbital carbamazepine

chloral hydrate * chlordiazepoxide

chlorthalidone cholestyramine *

clozapine corticotropin

cortisone

COUMADIN underdosage cyclophosphamide *

dicloxacillin ethchlorvynol

glutethimide griseofulvin

haloperidol meprobamate

6-mercaptopurine methimazole *

moricizine hydrochloride * nafcillin

paraldehyde pentobarbital

phenobarbital

phenytoin * pravastatin *

prednisone * primidone

propylthiouracil * raloxifene

ranitidine * rifampin

secobarbital spironolactone

sucralfate trazodone

vitamin C (high dose) vitamin K

Bromelains Capsicum 2 Garlic 5 Ginseng (Panax) 5 Inositol Nicotinate Onion 5

Botanticals with fibrinolytic properties:

Agrimony 4 Goldenseal Mistletoe Yarrow

Botanticals with coagulant properties:

Alfalfa Angelica (Dong Quai)

Aniseed Arnica

Asa Foetida Bogbean 1

Boldo Buchu

Capsicum 2 Cassia 3

Celery Chamomile

(German and Roman) Dandelion 3

Fenugreek Horse Chestnut

Horseradish Licorice 3

Meadowsweet 1 Nettle

Parsley Passion Flower

Prickly Ash (Northern) Quassia

Red Clover Sweet Clover

Sweet Woodruff Tonka Beans

Wild Carrot Wild Lettuce

Botanticals that contain coumarins with potential anticoagulant effects:

Agrimony 4

Aloe Gel

Aspen

Black Cohosh

Black Haw

Bogbean 1

Cassia 3

Clove

Dandelion 3

Feverfew

Garlic 5

German Sarsaparilla

Ginger

Ginkgo Biloba

Ginseng (Panax) 5

Licorice 3

Meadowsweet 1

Onion 5

Policosanol

Poplar

Senega

Tamarind

Willow

Wintergreen

Botanicals that contain salicylate and/ or have antiplatelet properties:

Such use of vitamin K 1 reduces response to subsequent COUMADIN therapy. Patients may return to a pretreatment thrombotic status following the rapid reversal of a prolonged PT/ INR. Resumption of COUMADIN (Warfarin Sodium) administration reverses the effect of vitamin K, and a therapeutic PT/ INR can again be obtained by careful dosage adjustment.