Diovan - Warnings & Precautions

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Concomitant Therapy in Patients with Heart Failure:

In patients with heart failure, concomitant use of Diovan, an ACE inhibitor, and a beta blocker is not recommended. In the Valsartan Heart Failure Trial, this triple combination was associated with an unfavorable heart failure outcome (see CLINICAL PHARMACOLOGY, Pharmacodynamics and Clinical Effects, Heart Failure).

Information for Patients

Pregnancy:

Female patients of childbearing age should be told about the consequences of second-and third-trimester exposure to drugs that act on the renin-angiotensin system, and they should also be told that these consequences do not appear to have resulted from intrauterine drug exposure that has been limited to the first trimester. These patients should be asked to report pregnancies to their physicians as soon as possible.