Levaquin - Indications & Dosage

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Patients with Normal Renal Function Infection* Unit Dose Freq. Duration** Daily Dose

Comm. Acquired Pneumonia 500 mg q24h 7-14 days 500 mg Comm. Acquired Pneumonia 750 mg*** q24h 5 days 750 mg

Nosocomial Pneumonia 750 mg q24h 7-14 days 750 mg Complicated SSSI 750 mg q24h 7-14 days 750 mg

Acute Bacterial Exacerbation of Chronic Bronchitis 500 mg q24h 7 days 500 mg

Acute Maxillary Sinusitis 500 mg q24h 10-14 days 500 mg Uncomplicated SSSI 500 mg q24h 7-10 days 500 mg

Chronic Bacterial Prostatitis 500 mg q24h 28 days 500 mg Complicated UTI 250 mg q24h 10 days 250 mg

Acute pyelonephritis 250 mg q24h 10 days 250 mg Uncomplicated UTI 250 mg q24h 3 days 250 mg

* DUE TO THE DESIGNATED PATHOGENS (See INDICATIONS AND USAGE.)

** Sequential therapy (intravenous to oral) may be instituted at the discretion of the physician.

*** Efficacy of this alternative regimen has only been documented for infections caused by penicillin-susceptible Streptococcus pneumoniae,

Haemophilus influenzae, Haemophilus parainfluenzae, Mycoplasma pneumoniae and Chlamydia pneumoniae.

Patients with Impaired Renal Function Renal Status Initial Dose Subsequent Dose

Acute Bacterial Exacerbation of Chronic Bronchitis / Comm. Acquired Pneumonia / Acute Maxillary Sinusitis /

Uncomplicated SSSI/ Chronic Bacterial Prostatitis CLCR from 50 to 80 mL/ min No dosage adjustment required

CLCR from 20 to 49 mL/ min 500 mg 250 mg q24h CLCR from 10 to 19 mL/ min 500 mg 250 mg q48h

Hemodialysis 500 mg 250 mg q48h CAPD 500 mg 250 mg q48h

Complicated SSSI/ Nosocomial Pneumonia/ Comm. Acquired Pneumonia

CLCR from 50 to 80 mL/ min No dosage adjustment required CLCR from 20 to 49 mL/ min 750 mg 750 mg q48h

CLCR from 10 to 19 mL/ min 750 mg 500 mg q48h Hemodialysis 750 mg 500 mg q48h

CAPD 750 mg 500 mg q48h

Complicated UTI / Acute Pyelonephritis CLCR 20 mL/ min No dosage adjustment required

CLCR from 10 to 19 mL/ min 250 mg 250 mg q48h

Uncomplicated UTI No dosage adjustment required CLCR =creatinine clearances

CAPD= chronic ambulatory peritoneal dialysis