Levaquin - Indications & Dosage

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When only the serum creatinine is known, the following formula may be

used to estimate creatinine clearance.

Men: Creatinine Clearance (mL/ min) =

Weight (kg) x (140 Ð age)

72 x serum creatinine (mg/ dL)

Women: 0.85 x the value calculated for men.

The serum creatinine should represent a steady state of renal function.

Preparation of Levofloxacin Injection for Administration LEVAQUIN Injection in Single-Use Vials: LEVAQUIN Injection is sup-plied in single-use vials containing a concentrated levofloxacin solution with the equivalent of 500 mg (20 mL vial) and 750 mg (30 mL vial) of levofloxacin in Water for Injection, USP. The 20 mL and 30 mL vials each contain 25 mg of levofloxacin/ mL.

THESE LEVAQUIN INJECTION SINGLE-USE VIALS MUST BE FURTHER DILUTED WITH AN APPROPRIATE SOLUTION PRIOR TO INTRAVENOUS ADMINISTRATION. (See COMPATIBLE INTRAVENOUS SOLUTIONS.) The concentration of the resulting diluted solution should be 5 mg/ mL prior to administration.

This intravenous drug product should be inspected visually for particu-late matter prior to administration. Samples containing visible particles should be discarded. Since no preservative or bacteriostatic agent is present in this product, aseptic technique must be used in preparation of the final intravenous solution. Since the vials are for single-use only, any unused portion remaining in the vial should be discarded. When used to prepare two 250 mg doses from the 20 mL vial containing 500 mg of levofloxacin, the full content of the vial should be withdrawn at once using a single-entry procedure, and a second dose should be prepared and stored for subsequent use. (See Stability of LEVAQUIN Injection Following Dilution.)

Since only limited data are available on the compatibility of levofloxacin intravenous injection with other intravenous substances, additives or other medications should not be added to LEVAQUIN Injection in single-use vials or infused simultaneously through the same intravenous line. If the same intravenous line is used for sequential infusion of several different drugs, the line should be flushed before and after infusion of LEVAQUIN Injection with an infusion solution compati-ble with LEVAQUIN Injection and with any other drug( s) administered via this common line.