Levaquin - Side Effects & Drug Interactions

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Red Blood Cell Disorders

Anemia

Reproductive Disorders

Dysmenorrhea, leukorrhea

Resistance Mechanism Disorders

Abscess, bacterial infection, fungal infection, herpes simplex, moniliasis, otitis media, sepsis, viral infection

Respiratory System Disorders

Airways obstruction, aspiration, asthma, bronchitis, bronchospasm, chronic obstructive airway disease, coughing, hemoptysis, epistaxis, hypoxia, laryngitis, pharyngitis, pleural effusion, pleurisy, pneumonitis, pneumonia, pneumothorax, pulmonary collapse, pulmonary edema, respiratory depression, respiratory insuf-ficiency, upper respiratory tract infection

Skin and Appendages Disorders

Alopecia, bullous eruption, dry skin, eczema, genital pruritus, increased sweat-ing, rash, skin exfoliation, skin ulceration, urticaria

Urinary System Disorders

Abnormal renal function, acute renal failure, dysuria, hematuria, oliguria, urinary incontinence, urinary retention, urinary tract infection

Vascular (Extracardiac) Disorders: Flushing, gangrene, phlebitis, purpura, thrombophlebitis (deep)

Vision Disorders

Abnormal vision, eye pain, conjunctivitis

White Cell and RES Disorders

Agranulocytosis, granulocytopenia, leuko-cytosis, lymphadenopathy

In clinical trials using multiple-dose therapy, ophthalmologic abnormal-ities, including cataracts and multiple punctate lenticular opacities, have been noted in patients undergoing treatment with other quinolones. The relationship of the drugs to these events is not presently established.

Crystalluria and cylindruria have been reported with other quinolones. The following markedly abnormal laboratory values appeared in >2% of patients receiving levofloxacin. It is not known whether these abnormali-ties were caused by the drug or the underlying condition being treated.

Blood Chemistry: decreased glucose (2.2%)

Hematology: decreased lymphocytes (2.2%)

Post-Marketing Adverse Reactions

Additional adverse events reported from worldwide post-marketing experience with levofloxacin include: allergic pneumonitis, anaphylactic shock, anaphylactoid reaction, dysphonia, abnormal EEG, encephalopathy, eosinophilia, erythema multiforme, hemolytic anemia, multi-system organ failure, increased International Normalized Ratio (INR)/ prothrombin time, Stevens-Johnson Syndrome, tendon rupture, torsades de pointes, vasodilation.