Graves disease

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Endocrine glands

Graves' disease

Thyroid enlargement - scintiscan

Thyroid gland

Diffuse thyrotoxic goiter

The purpose of treatment is to control the overactivity of the thyroid gland. Beta-blockers such as propranolol are often used to treat symptoms of rapid heart rate, sweating, and anxiety until the hyperthyroidism is controlled. Hyperthyroidism is treated with antithyroid medications, radioactive iodine, or surgery.

Both radiation and surgery result in the need for lifelong use of replacement thyroid hormones, because these treatments destroy or remove the gland.

The eye problems related to Graves disease usually disappear when medications, radiation, or surgery solve the hyperthyroidism problem. Sometimes use of prednisone (a steroid medication, which suppresses the immune system) is required to reduce eye irritation and swelling.

Taping the eyes closed at night to prevent drying may sometimes be required. Sunglasses and eyedrops may lessen irritation of the eyes. Rarely, surgery may be needed to return the eyes to their normal position.

For most people, Graves disease responds well to treatment. However, thyroid surgery or radioactive iodine will sometimes cause hypothyroidism, which can lead to weight gain, depression, and mental and physical sluggishness. Antithyroid medications can also have serious side effects.

• Eye problems associated with the disease (called Graves ophthalmopathy or exophthalmos)
• heart complications including rapid heart rate, congestive heart failure (especially in the elderly) and atrial fibrillation
• Thyroid crisis (thyrotoxic storm), a severe worsening of the symptoms of an overactive thyroid gland
• Increased risk for osteoporosis
• Inadequate levels of thyroid hormone medications following surgery or radiation, leading to fatigue, elevated cholesterol levels, mild weight gain, depression, and mental and physical sluggishness
• Complications related to surgery, including:
  • Visible scarring of the neck
  • Hoarseness due to damage of the nerve leading to the voice box
  • Low calcium levels due to damage to the parathyroid glands

Call your health care provider if you have symptoms suggestive of Graves disease. Also call if eye problems or general symptoms get worse (or do not improve) with treatment.

Go to the emergency room or call the local emergency number (such as 911) if symptoms of hyperthyroidism are associated with a rapid, irregular heart beat, fever, or a decrease in consciousness.

Review Date: 08/08/2006
Reviewed By: Robert Hurd, MD, Department of Biology, College of Arts and Sciences, Xavier University, Cincinnati, OH. Review provided by VeriMed Healthcare Network