Primary hyperparathyroidism

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Endocrine glands

Parathyroid glands

Parathyroid-related hypercalcemia

• Fatigue
• Fractures
• Decreased height
• Upper abdominal pain
• Loss of appetite
• Nausea
• Muscular weakness
• Muscle pain
• Depression
• Personality changes
• Stupor and possibly coma
• Kidney stones
• Increased urination

• A test called radioimmunoassay shows an increased level of PTH.
• Serum calcium is increased.
• Serum phosphorus may be decreased.
• Serum alkaline phosphatase may be increased.
• Bone x-ray may show bone reabsorption (the body breaks down the bone), or fractures.
• Imaging of the kidneys or ureters may show calcification or blockage.
• ECG may show abnormalities.

This disease may cause changes in the results of the following tests:

• Calcium - urine
• Calcium (ionized)
• Bone density
• Markers of bone resorption (N-telopeptide, pyridinoline, and deoxypyridinoline)

Review Date: 08/08/2006
Reviewed By: Robert Hurd, MD, Department of Biology, College of Arts and Sciences, Xavier University, Cincinnati, OH. Review provided by VeriMed Healthcare Network.