Multiple Endocrine Neoplasia Type I

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Endocrine glands

Wermer syndrome; MEN I

Symptoms vary greatly from person to person. They may include:

• Abdominal pain
• Burning, aching, or hunger discomfort in the upper abdomen or lower chest that is relieved by antacids, milk, or food
• Black, tarry stools
• Nausea and vomiting
• Bloated feeling after meals
• Weakness
• Headache
• Vision problems
• Loss of coordination
• Anxiety
• Mental changes or confusion
• Coma (if hypoglycemia is untreated)
• Loss of appetite
• Muscle pain
• Fatigue
• Sensitivity to the cold
• Unintentional weight loss
• Low blood pressure
• Loss of underarm or pubic hair
• In women, cessation of menses, infertility, or failure to produce breast milk
• In men, decreased sexual interest, loss of body or facial hair

Tests to diagnose MEN I may include:

• MRI of abdomen
• MRI of the head
• CT of abdomen
• Cranial CT scan
• Parathyroid biopsy
• Insulin test
• Fasting blood sugar
• Serum glucagon
• Serum gastrin
• Serum calcium
• Serum parathyroid hormone
• Serum prolactin
• Serum thyroid stimulating hormone (rarely used)
• Cortisol
• Serum adrenocorticotropic hormone
• Serum luteinizing hormone
• Serum follicle stimulating hormone

Review Date: 10/25/2006
Reviewed By: Robert Hurd, M.D., Department of Biology, College of Arts and Sciences, Xavier University, Cincinnati, OH. Review provided by VeriMed Healthcare Network.