Multiple Endocrine Neoplasia (MEN) II


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Endocrine glands
Definition

Multiple endocrine neoplasia II (MEN II) is an uncommon condition passed down through families (inherited) marked by overactivity of the thyroid, adrenal, and parathyroid glands.


Alternative Names

Sipple's syndrome


Causes, incidence, and risk factors

The cause of MEN II is a defect in a gene called RET. This defect causes many tumors to appear in the same person, but not necessarily at the same time. The type of adrenal tumor is a pheochromocytoma, and the thyroid tumor is a medullary carcinoma of the thyroid.

The disorder may occur at any age, and affects men and women equally. The main risk factor is a family history of MEN II.



Review Date: 10/25/2006
Reviewed By: Robert Hurd, M.D., Department of Biology, College of Arts and Sciences, Xavier University, Cincinnati, OH. Review provided by VeriMed Healthcare Network.


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