Necrotizing vasculitis

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Circulatory system

Vasculitis - necrotizing

• Skin lesion
  • Papule (small, solid, and raised lesion)
  • Lesions red or purple (purpuric)
  • Lesions on the legs, hands, or other areas
• Fingers that change color (blueness of the fingers or toes)
• Infarction (tissue death due to lack of oxygen)
  • Pain or tenderness in the area
  • Redness (if superficial area)
  • Non-healing ulcers
• Joint pain (such as knee pain, elbow pain)
• Abdominal pain
• Pain, numbness, tingling in an extremity or any area
• Changes or decrease in function of an extremity or any area
• Fever

• Weakness
• Swallowing difficulty
• Speech impairment
• Leg pain
• Muscle contractions
• Muscle atrophy
• Movement difficulty
• Painful menstruation
• Hoarseness or changing voice
• Fatigue
• Pupils that are different size
• Eyelid drooping

Examination findings may vary depending on the part of the body affected by the necrotizing vasculitis. Neurologic examination may show single or multiple neuropathy (nerve damage).

• A biopsy of the suspected muscle, nerve biopsy, or organ or tissue biopsy shows vasculitis.
• A chest x-ray indicates lesions of the chest.
• A sedimentation rate that is elevated (nonspecific finding).
• A urinalysis shows blood, casts, urine protein, or other abnormalities.
• Hepatitis blood tests are positive.
• Blood test for antibodies against neutrophils (ANCA antibodies); these antibodies are often seen in vasculitic disorders.

Review Date: 08/02/2005
Reviewed By: Ariel D. Teitel, M.D., M.B.A., Chief, Division of Rheumatology, St. Vincent's Hospital, New York, NY. Review provided by VeriMed Healthcare Network.