Sjogren syndrome

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Antibodies

Sjogren syndrome is a systemic inflammatory disorder characterized by dry mouth, decreased tearing, and other dry mucous membranes. It is often associated with autoimmune rheumatic disorders.

The cause of Sjogren syndrome is unknown. The syndrome occurs most often in women 40 to 50 years old. It is rare in children. Pediatric patients usually present with another autoimmune disorder before developing the signs of Sjogren syndrome.

Dryness of the eyes and mouth are the most common symptoms of this syndrome; they may occur alone, or with symptoms associated with rheumatoid arthritis or other connective tissue diseases. There may be an associated enlargement of the salivary glands. Other organs may become affected. The syndrome may be associated with rheumatoid arthritis, systemic lupus erythematosus, scleroderma, polymyositis, and other diseases. Sjogren syndrome affects 3% of the population.

Review Date: 04/20/2005
Reviewed By: Stanford Peng, M.D., Ph.D., Division of Rheumatology, Washington University School of Medicine, St. Louis, MO. Review provided by VeriMed Healthcare Network.