Membranoproliferative GN II

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Kidney anatomy

Membranoproliferative glomerulonephritis (type II); Glomerulonephritis - membranoproliferative (type II); Mesangiocapillary glomerulonephritis (type II); Dense deposit disease; MPGN II

• Blood in the urine
• Dark urine (smoke, cola, or tea colored)
• Cloudy urine
• Decrease in urine volume
• Swelling of any part of the body
• Changes in mental status
  • decreased alertness
  • decreased concentration

The results of a physical examination vary depending on the symptoms of the disorder. Edema (swelling) is common, along with signs of fluid overload such as abnormal sounds on auscultation of the heart and lungs. Blood pressure is often elevated.

These tests help confirm the diagnosis:

• Abnormal urinalysis:
  • white blood cells, urine
  • red blood cells in urine
  • protein, urine
  • or other abnormalities.
• Possible increase in BUN and creatinine, indicating decreased kidney function.
• Possible decrease in serum complement levels indicating immune system involvement.
• Possible presence of serum complement C3 nephritic factor.

A kidney biopsy confirms the diagnosis of membranoproliferative glomerulonephritis type II.

Review Date: 09/13/2005
Reviewed By: Robert Mushnick, M.D., Clinical Assistant Professor, SUNY Downstate Health Center, Brooklyn, NY. Review provided by VeriMed Healthcare Network.