Focal segmental glomerulosclerosis

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Male urinary system

Segmental glomerulosclerosis; Focal sclerosis with hyalinosis

• Foamy urine
• Swelling of the body, called generalized edema, from retained fluids
• Weight gain
• Poor appetite

There are no strong clues to the diagnosis on physical examination, other than evidence of edema and elevated blood pressure. Evidence of chronic renal failure and associated fluid overload may develop as the illness progresses.

Tests may include:

• A urinalysis, which shows protein, with or without small amounts of blood.
• A renal biopsy, which shows scarring of parts of some.
• An immunofluorescence microscopy test showing deposits of the antibody IgM.

Review Date: 06/13/2005
Reviewed By: Debbie Cohen, M.D., Renal and Electrolyte Division, University of Pennsylvania Medical Center, Philadelphia, PA. Review provided by VeriMed Healthcare Network.