Proximal renal tubular acidosis

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Kidney anatomy

Kidney - blood and urine flow

Renal tubular acidosis - proximal; Type II RTA; RTA - proximal; Renal tubular acidosis type II

The goal is to restore the normal pH (acid-base level) and a normal electrolyte balance to the body. This will indirectly correct bone disorders and reduce the risk of osteomalacia and osteopenia in adults.

Some adults may need no treatment. All children need alkaline medication to prevent bone disease (rickets in particular) and to permit normal growth. The underlying cause should be corrected if it can be identified.

Alkaline medications include sodium bicarbonate and potassium citrate. They correct the acidic condition of the body and correct low potassium levels. Thiazide diuretics may indirectly decrease bicarbonate loss but may exacerbate the low potassium levels.

Vitamin D and calcium supplements may be needed to aid in the reduction of skeletal deformities resulting from osteomalacia or rickets.

Although the underlying cause of proximal renal tubular acidosis may go away by itself, the effects and complications can be permanent or life-threatening. Treatment is usually successful.

• osteomalacia
• rickets
• electrolyte disturbances, such as hypokalemia

Call your health care provider if you have symptoms of proximal renal tubular acidosis.

Call your health care provider if new symptoms develop, including pain in the bones, back, flank, or abdomen; skeletal deformities, increased heart rate or irregular heartbeat, muscle cramps, decreased urine output, bloody urine, or other symptoms.

Get medical help immediately if decreased alertness or orientation, decreased consciousness, or seizures develop.

Review Date: 12/09/2005
Reviewed By: Colm C. Magee, MD, MPH, Medical Director, Renal Transplant, Brigham & Women's Hospital, and Assistant Professor, Harvard Medical School, Boston, MA. Review provided by VeriMed Healthcare Network.