Diabetes insipidus - nephrogenic

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Male urinary system

Nephrogenic diabetes insipidus; Acquired nephrogenic diabetes insipidus;

The goal of treatment is to regulate fluid levels in the body.

All cases should be treated with consistently high fluid intake. The volume of fluids consumed should approximately equal the volume of urine produced.

Reduction or discontinuation of medications that may cause nephrogenic DI may improve symptoms.

Hydrochlorothiazide may improve symptoms. This may be used alone or in combination with other medications, including indomethacin. Although this medication is a diuretic (these medications are usually used to increase urine output), in certain cases hydrochlorothiazide can actually reduce urine output for people with nephrogenic DI.

This medication works by causing sodium and water to be excreted in the early part of the renal tubules (the proximal tubules).

This leaves less fluid available for the late portion of the kidney (distal tubule) to excrete -- this is the portion affected by nephrogenic DI -- and thus it limits the total volume of urine that can be excreted.

Congenital nephrogenic DI is a chronic condition requiring lifelong treatment. Acquired nephrogenic DI may be short-term or long-term.

• Severe dehydration, shock (if inadequate fluid intake)
• Hypernatremia (high blood sodium)
• Dilation of the ureters and bladder

Call your health care provider if symptoms indicate diabetes insipidus may be present.

Review Date: 12/09/2005
Reviewed By: Colm C. Magee, MD, MPH, Medical Director, Renal Transplant, Brigham & Women's Hospital, and Assistant Professor, Harvard Medical School, Boston, MA. Review provided by VeriMed Healthcare Network.