Cancer - renal pelvis or ureter

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Kidney anatomy

The kidneys collect urine in a section called the pelvis. The pelvis and its subdivisions (calyces) empty urine into a tube called the ureter, which leads to the bladder. Cancer can grow in this urine collection system, but is uncommon.

Transitional cell cancer of the renal pelvis or ureter

As a group, renal pelvis and ureter cancers account for no more than 5% of all cancers of the kidney and upper urinary tract. They affect men more often than women and are more common in people older than 65.

Tumors of the renal pelvis and ureter are usually transitional cell cancers. Approximately 10% are squamous cell carcinomas.

The causes of this cancer are not completely known. Chronic (long-term) irritation of the kidney from harmful substances excreted in the urine may be a factor and may result from the following:

• Smoking
• Analgesic nephropathy
• Exposure to aniline dyes and chemicals used in the manufacturing of leather goods, textiles, plastics, and rubber

Patients with a previous history of bladder cancer are also at risk.

Review Date: 09/11/2006
Reviewed By: Rita Nanda, M.D., Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.