Glucose-6-phosphate dehydrogenase deficiency

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Blood cells

G-6-PD deficiency; Hemolytic anemia due to G6PD deficiency; Anemia - hemolytic due to G6PD deficiency

• Fatigue
• Paleness
• Shortness of breath
• Rapid heart rate
• Yellow skin color (jaundice)
• Dark urine
• Enlarged spleen

• Anemia
• Hemolysis
• Reduced G-6-PD activity
• Reticulocytosis following a hemolytic crisis

• Elevated bilirubin levels
• Elevated serum LDH
• Low serum haptoglobin
• Hemoglobin in the urine
• Elevated absolute reticulocyte count
• Low red blood cell count and hemoglobin
• Heinz bodies present on examination of the peripheral blood smear using special stains
• Methylene blue test
• Methemoglobin reduction test

Review Date: 04/15/2005
Reviewed By: Rita Nanda, MD, Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.