Primary myelofibrosis

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Myelofibrosis; Idiopathic myelofibrosis; Myeloid metaplasia; Agnogenic myeloid metaplasia

• Fatigue
• Abdominal fullness related to an enlarged spleen
• Easy bleeding
• Bone pain
• Pallor (paleness)
• Shortness of breath on exertion
• Bruising
• Increased susceptibility to infection

Physical examination shows an enlarged spleen. Later in the disease, it may also show an enlarged liver.

• An examination of the blood shows teardrop-shaped red blood cells.
• The white blood cell count is variable.
• The platelet count is variable.
• Bone marrow biopsy may be performed to rule out other causes of the symptoms.
• CBC (complete blood count) shows a low red blood cell count .

Review Date: 04/15/2005
Reviewed By: Rita Nanda, MD, Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.