Hemophilia B

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Blood cells	Blood clots	X-linked recessive genetic defects	X-linked recessive genetic defects - how boys are affected
X-linked recessive genetic defects - how girls are affected

Christmas disease; Factor IX hemophilia

• Nosebleeds
• Bruising
• Spontaneous bleeding
• Bleeding into joints and associated pain and swelling
• Gastrointestinal tract and urinary tract hemorrhage
• Blood in the urine or stool
• Prolonged bleeding from cuts, tooth extraction, and surgery
• Excessive bleeding following circumcision

Coagulation studies involving many tests are performed if the person tested is the first one in the family to have a bleeding disorder. Once the defect has been identified, other family members will need less testing to diagnose the disorder.

• PTT is prolonged.
• Prothrombin time is normal.
• Bleeding time is normal.
• Fibrinogen level is normal.
• Serum factor IX is reduced.

Review Date: 05/03/2006
Reviewed By: William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.