Paroxysmal cold hemoglobinuria (PCH)

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Blood cells

PCH

• Chills
• Fever
• Back pain
• Leg pain
• Abdominal pain
• Headache
• General discomfort, uneasiness, or ill feeling (malaise)
• Blood in the urine (red urine)

• Positive Donath-Landsteiner test
• Serum hemoglobin increased during attacks
• Urine hemoglobin increased
• CBC shows anemia
• Coombs test is negative
• Bilirubin is elevated
• LDH is elevated

Review Date: 04/15/2005
Reviewed By: Rita Nanda, MD, Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.