Thalassemia

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Thalassemia major

Thalassemia minor

Mediterranean anemia; Cooley's anemia

• Fatigue
• Shortness of breath
• Jaundice
• Bone deformities in the face

• Enlarged spleen
• Peripheral blood smear shows small, abnormally-shaped red blood cells
• Complete blood count shows anemia
• Hemoglobin electrophoresis shows abnormal hemoglobin

• RBC indices (size, hemoglobin content)
• Osmotic fragility

Review Date: 10/30/2006
Reviewed By: William Matsui, MD, Assistant Professor of Oncology, Division of Hematologic Malignancies, The Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins, Baltimore, MD. Review provided by VeriMed Healthcare Network.