General paresis

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Central nervous system

The goals of treatment are to cure the infection and reduce progression of the disorder. Treatment of the infection will reduce new nerve damage, but will not cure existing damage. Penicillin or other antibiotics, such as doxycycline, are given to treat the infection. Treatment may be prolonged to ensure that the infection is completely cleared. A follow-up examination of the cerebrospinal fluid is required to evaluate the effectiveness of antibiotic therapy.

Symptomatic treatment is required for existing neurologic damage. Emergency treatment of seizures may be required. Anticonvulsants (such as phenytoin) may be needed to control seizures.

Assistance or supervision with such activities as eating and dressing may be needed if patients are unable to care for themselves. Physical therapy, occupational therapy, or other interventions may be appropriate for people with muscle weakness.

Progressive disability is likely. People with late syphilis infections are more prone to the development of other infections and diseases. If not treated, progressive disability is likely.

Complications include the inability to care for oneself, the inability to communicate or interact, injury caused during seizures, and injury from falls (related to unsteady gait).

Call your health care provider if the symptoms of general paresis are present, particularly if there is a known history of syphilis infection.

Go to the emergency room or call the local emergency number (such as 911) if seizures occur.

Review Date: 04/28/2006
Reviewed By: Daniel Kantor, M.D., Director of the Comprehensive MS Center, Neuroscience Institute, University of Florida Health Science Center, Jacksonville, FL. Review provided by VeriMed Healthcare Network.