Major depression with psychotic features

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Forms of depression

Psychotic depression; Delusional depression

Treatment generally involves antidepressant and antipsychotic medication. The antipsychotics are sometimes given briefly. Electroconvulsive therapy is very effective for this condition, but it is generally a second-line treatment.

The presence of psychotic features in depression reflects a more serious condition. Generally, the depressive symptoms have a higher chance of returning than the psychotic symptoms. Patients may need to take medication for a long time to prevent depression from returning.

Ongoing treatment and monitoring give the patient the best chance of recovery and doing well on an ongoing basis.

Suicide or other self-harm is the most serious complication. Patients may need to be hospitalized if they have thoughts of suicide. The safety of others must also be considered.

Call your health care provider if you or someone you know experiences depression or psychosis.

Review Date: 05/08/2006
Reviewed By: Paul Ballas, D.O., Department of Psychiatry, Thomas Jefferson University Hospital, Philadelphia, PA. Review provided by VeriMed Healthcare Network.