Hartnup disorder

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• Supplements containing nicotinamide are often the main treatment. This can effectively treat the rash, and can sometimes treat the uncoordination and psychiatric symptoms.
• A high protein diet is recommended.
• Avoiding sun exposure by wearing protective clothing and using a sunscreen of 15 factor or higher is recommended.
• Psychiatric treatment, such as the use of antidepressants or mood stabilizers, may be needed if mood swings or psychiatric problems occur.

Most people with this disorder can expect a normal lifespan with no disability. Rarely, there have been reports of severe bouts of neurologic disease and even deaths in families with this disorder.

There are usually no complications. The minority of people who develop symptoms can experience rash, uncoordinated movements, and, less frequently, psychiatric symptoms.

Call for an appointment with your health care provider if you have symptoms suggestive of this condition, particularly if you have a family history of Hartnup disorder. Genetic counseling is recommended if you have a family history of this condition and are planning a pregnancy.

Review Date: 08/11/2006
Reviewed By: Brian Kirmse, MD, Mount Sinai School of Medicine, Department of Human Genetics, New York, NY. Review provided by VeriMed Healthcare Network.