Transfusion reaction

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Surface proteins causing rejection

Blood transfusion reaction

The goal of treatment is to prevent or treat severe effects of transfusion reaction. If symptoms occur during the transfusion, the transfusion is stopped. Blood samples from the person receiving the transfusion (and from remaining donor blood) may be tested to confirm that symptoms are caused by transfusion reaction.

Mild symptoms may be treated according to the symptom. Antihistamines such as diphenhydramine may reduce itching and rash. Acetaminophen may be recommended to reduce fever and discomfort. Corticosteroids such as prednisone or dexamethasone may be given to reduce the immune response. Intravenous fluids and various medications may be used to treat/prevent kidney failure and shock.

The outcome varies depending on the severity of the reaction. The disorder may disappear completely and without problems. However, it may be severe and life threatening.

• Discomfort
• Anemia
• Acute kidney failure
• Shock
• Lung disfunction

Notify your health care provider if a blood transfusion is planned and previous transfusion reaction has occurred.

Review Date: 02/01/2005
Reviewed By: Rita Nanda, M.D., Department of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.