Malignant hyperthermia

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Hyperthermia - malignant; Hyperpyrexia - malignant

• Rapid rise in temperature after general anesthesia is given
• Muscle rigidity and stiffness after general anesthesia is given
• Dark brown urine
• Muscle ache without obvious exercise to explain sore muscles
• Family history of malignant hyperthermia or unexplained death during anesthesia

• Blood chemistry ( chem-20 ) shows increased blood levels of creatine phosphokinase (CPK ), potassium, uric acid, phosphate.
• Myoglobin in the urine is elevated.
• Muscle biopsy may show abnormal results in response to certain drugs such as caffeine and halothane (an anesthetic) and abnormal muscle fibers.
• Genetic testing such as ryanodine receptor (RYR1) may show gene abnormalities.
• Phosphorus magnetic resonance spectroscopy, a research test, may show abnormal muscle function.

Review Date: 09/08/2005
Reviewed By: Neal Sondheimer, M.D., PhD., Division of Genetics and Metabolism, Children's Hospital of Philadelphia, Philadelphia, PA. Review provided by VeriMed Healthcare Network.