Hepatocerebral degeneration

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Liver anatomy

Hepatocerebral degeneration is a brain disorder caused by liver damage. This "Non-Wilsonian" type means that the liver damage is not caused by the deposition of copper in the liver, which is a key feature of Wilson's disease. This longstanding (chronic) condition may lead to irreversible neurological (nervous system) symptoms.

Chronic acquired (Non-Wilsonian) hepatocerebral degeneration

Liver damage can lead to the accumulation of ammonia and other toxic materials in the body. This happens when the liver doesn't work properly to break down and release these chemicals The toxic materials can destroy brain tissue, leading to coma, other neurological problems, and potentially death. Specific brain areas, such as the basal ganglia, appear to be more susceptible to injury caused by liver failure. Since the basal ganglia are involved in the regulation of movement, people affected by this disorder may develop tremors, twitching, involuntary movements, and other symptoms.

This type of chronic acquired hepatocerebral degeneration, and the neurological syndrome it causes, may occur in any case of acquired liver failure including hepatitis.

Review Date: 09/07/2006
Reviewed By: Kenneth Gross, M.D., Neurology, North Miami, FL. Review provided by VeriMed Healthcare Network.