Rh incompatibility

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Antibodies	Erythroblastosis fetalis, photomicrograph	Exchange transfusion - series	Jaundice infant
Rh incompatibility - series

Rh-induced hemolytic disease of the newborn; Hydrops fetalis

• Polyhydramnios (before birth)
• Slowly or rapidly increasing jaundice
• Prolonged jaundice
• Hypotonia
• Motormental retardation

Mild Rh incompatibility:

• Positive direct Coombs
• Evidence of hemolysis in the infant's blood
• Elevated cord blood bilirubin

• Severe anemia
• Heart failure (cardiac failure)
• Enlarged liver (hepatomegaly)
• Respiratory distress
• Bruising or purplish bruise-like lesions on the skin (purpura)

• High bilirubin level (greater than 18 mg/cc)
• Extreme jaundice
• Absent Moro (startle) reflex
• Poor breast-feeding or sucking
• Lethargy

• High-pitched cry
• Arched back with neck hyperextended backwards (opisthotonos)
• Bulging fontanel (soft spot)
• Seizures

• High-frequency hearing loss
• Mental retardation
• Muscle rigidity
• Speech difficulties
• Seizures
• Movement disorder

Review Date: 08/18/2006
Reviewed By: Benjamin W. Van Voorhees, MD, MPH, Assistant Professor of Medicine and Pediatrics, The University of Chicago, Chicago, IL. Review provided by VeriMed Healthcare Network.