Rh incompatibility

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Antibodies	Erythroblastosis fetalis, photomicrograph	Exchange transfusion - series	Jaundice infant
Rh incompatibility - series

Rh-induced hemolytic disease of the newborn; Hydrops fetalis

Since Rh incompatibility is almost completely preventable with the use of RhoGAM, prevention remains the best treatment. Treatment of the already affected infant depends on the severity of the condition.

Mild:

• Aggressive hydration
• Phototherapy using bilirubin lights

• Amniocentesis to determine severity
• Intrauterine fetal transfusion
• Early induction of labor
• A direct transfusion of packed red blood cells (compatible with the infant's blood) and also exchange transfusion of the newborn to rid the blood of the maternal antibodies that are destroying the red blood cells
• Control of congestive failure and fluid retention

• Exchange transfusion (may require multiple exchanges)
• Phototherapy

Full recovery is expected for mild Rh incompatibility. Both hydrops fetalis and kernicterus represent extreme conditions caused by hemolysis. Both have guarded outcomes. Hydrops fetalis has a high mortality rate.

Possible complications include neurological syndrome with mental deficiency, movement disorder, hearing loss, speech disorder, and seizures.

Call your health care provider if you think or know you are pregnant and have not yet seen a doctor.

Review Date: 08/18/2006
Reviewed By: Benjamin W. Van Voorhees, MD, MPH, Assistant Professor of Medicine and Pediatrics, The University of Chicago, Chicago, IL. Review provided by VeriMed Healthcare Network.