Neonatal cystic fibrosis screening

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Infant blood sample

Cystic fibrosis screening - neonatal; Immunoreactive trypsinogen; IRT test 

The predicted value of a normal or negative test is an immunoreactive trypsinogen value less than 140 ng/dL.

Note: ng/dL = nanograms per deciliter

If your child's level of immunoreactive trypsinogen is greater than 140 ng/dL on the first screen, the test result is considered positive. If your child's level is 120 ng/dL on the second screen, the second test result is also considered positive.

Although these two test results indicate CF may exist, a sweat test with a positive result is necessary to confirm the diagnosis.

Review Date: 05/16/2005
Reviewed By: John Goldenring, M.D., MPH, Department of Pediatrics, Children's Hospital, San Diego, CA. Review provided by VeriMed Healthcare Network.