Therapeutic drug levels

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Flecainide - serum; Digoxin - serum; Ethosuximide - serum; Disopyramide - serum; Digitoxin - serum; Lidocaine - serum; Kanamycin - serum; Gentamicin - serum; Imipramine - serum; Lithium - serum; Amikacin - serum; Acetaminophen - serum; Aminophylline - serum; TDM; Desipramine - serum; Chloramphenicol - serum; Amitriptyline - serum; Carbamazepine - serum; Methotrexate - serum; Therapeutic drug monitoring; Theophylline - serum; Tobramycin - serum; Valproic acid - serum; Quinidine - serum; Serum drug levels; Salicylate - serum; Propranolol - serum; Phenytoin - serum; Phenobarbital - serum; Procainamide - serum; Primidone - serum; Nortriptyline - serum

Following are some of the drugs that are commonly checked, and their therapeutic levels:

• Acetaminophen: varies with use
• Amikacin: 15 to 25 mcg/ml
• Aminophylline: 10 to 20 mcg/ml
• Amitriptyline: 120 to 150 ng/ml
• Carbamazepine: 5 to 12 mcg/ml
• Chloramphenicol: 10 to 20 mcg/ml
• Desipramine: 150 to 300 ng/ml
• Digitoxin: 15 to 20 ng/ml
• Digoxin: 0.8 to 2.0 ng/ml
• Disopyramide: 2 to 5 mcg/ml
• Ethosuximide: 40 to 100 mcg/ml
• Flecainide: 0.2 to 1.0 mcg/ml
• Gentamicin: 5 to 10 mcg/ml
• Imipramine: 150 to 300 ng/ml
• Kanamycin: 20 to 25 mcg/ml
• Lidocaine: 1.5 to 5.0 mcg/ml
• Lithium: 0.8 to 1.2 mEq/L
• Methotrexate: greater than 0.01 mcmol
• Nortriptyline: 50 to 150 ng/ml
• Phenobarbital: 10 to 30 mcg/ml
• Phenytoin: 10 to 20 mcg/ml
• Primidone: 5 to 12 mcg/ml
• Procainamide: 4 to 10 mcg/ml
• Propranolol: 50 to 100 ng/ml
• Quinidine: 2 to 5 mcg/ml
• Dalicylate: 100 to 250 mcg/ml
• Theophylline: 10 to 20 mcg/ml
• Tobramycin: 5 to 10 mcg/ml
• Valproic acid: 50 to 100 mcg/ml

Note:

• mcg/ml = microgram per milliliter
• ng/ml = nanogram per milliliter
• mEq/L = milliequivalents per liter
• mcmol = micromole

Following are some of the drugs that are commonly checked, and their toxic levels:

• Acetaminophen: greater than 250 mcg/ml
• Amikacin: greater than 25 mcg/ml
• Aminophylline: greater than 20 mcg/ml
• Amitriptyline: greater than 500 ng/ml
• Carbamazepine: greater than 12 mcg/ml
• Chloramphenicol: greater than 25 mcg/ml
• Desipramine: greater than 500 ng/ml
• Digitoxin: greater than 25 ng/ml
• Digoxin: greater than 2.4 ng/ml
• Disopyramide: greater than 5 mcg/ml
• Ethosuximide: greater than 100 mcg/ml
• Flecainide: greater than 1.0 mcg/ml
• Gentamicin: greater than 12 mcg/ml
• Imipramine: greater than 500 ng/ml
• Kanamycin: greater than 35 mcg/ml
• Lidocaine: greater than 5 mcg/ml
• Lithium: greater than 2.0 mEq/L
• Methotrexate: greater than 10 mcmol over 24-hours
• Nortriptyline: greater than 500 ng/ml
• Phenobarbital: greater than 40 mcg/ml
• Phenytoin: greater than 30 mcg/ml
• Primidone: greater than 15 mcg/ml
• Procainamide: greater than 16 mcg/ml
• Propranolol: greater than 150 ng/ml
• Quinidine: greater than 10 mcg/ml
• Dalicylate: greater than 300 mcg/ml
• Yheophylline: greater than 20 mcg/ml
• Yobramycin: greater than 12 mcg/ml
• Balproic acid: greater than 100 mcg/ml

Note:

• mcg/ml = microgram per milliliter
• ng/ml = nanogram per milliliter
• mEq/L = milliequivalents per liter
• mcmol = micromole

Review Date: 10/27/2005
Reviewed By: Frank A. Greco, M.D., Ph.D., Director, Biophysical Laboratory, The LaheyClinic, Burlington, MA. Review provided by VeriMed Healthcare Network.