17-hydroxycorticosteroids

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Urine sample

17-OHCS

Normal values are as follows:

• Male: 4 to 14 mg/24 hr
• Female: 2 to 12 mg/24 hr

Note: mg/24 hr = milligrams per 24 hours

Normal value ranges may vary slightly among different laboratories.

Elevated levels of 17-OHCS may indicate:

• Cushing's syndrome caused by adrenal tumor
• Cushing's syndrome caused by pituitary tumor
• Ectopic ACTH-producing tumor
• Severe physical or emotional stress

Elevated levels may also exist with:

• Obesity
• Pregnancy
• Severe hypertension
• Hydrocortisone therapy

Lower than normal levels of 17-OHCS may indicate:

• Adrenal hemorrhage
• Adrenal insufficiency (suppressed from steroid therapy)
• Adrenal infarction
• Hereditary enzyme deficiency
• Hypopituitarism
• Surgical removal of the adrenal gland

Review Date: 03/03/2006
Reviewed By: David Juan, MD, Specializing in Endocrinology Issues, Good Hand Medical Center and Alperin Medical Clinics, Santa Clara, CA. Review provided by VeriMed Healthcare Network.