LDH

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This is a blood test that measures the amount of lactate dehydrogenase (LDH). See also LDH isoenzymes.

Lactate dehydrogenase; Lactic acid dehydrogenase

Blood is drawn from a vein or from a heel, finger, toe, or earlobe. The laboratory centrifuges the blood to separate the serum (liquid portion) from the cells, and the LDH test is done on the serum.

Your health care provider may advise you to withhold drugs that may affect the test. Drugs that can increase LDH measurements include anesthetics, aspirin, clofibrate, fluorides, mithramycin, narcotics, and procainamide.

LDH is most often measured to evaluate the presence of tissue damage. The enzyme LDH is in many body tissues, especially the heart, liver, kidney, skeletal muscle, brain, blood cells, and lungs.

LDH catalyzes the interconversion of pyruvate and lactate. Exercising muscles convert (and red blood cells metabolize) glucose to lactate. Lactate is released into the blood and is eventually taken up by the liver. The liver converts lactate back to glucose and releases glucose into the blood. This glucose is then taken up by resting muscles, red blood cells, and other tissues.

Review Date: 04/15/2005
Reviewed By: Rita Nanda, MD, Department of Medicine, Section of Hematology/Oncology, University of Chicago Medical Center, Chicago, IL. Review provided by VeriMed Healthcare Network.