CSF VDRL test

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CSF test for syphilis

The CSF-VDRL test is used to diagnose neurosyphilis. This test looks for antibodies called reagins, which are sometimes produced by the body in reaction to the syphilis-causing bacteria.

Venereal Disease Research Laboratory slide test - CSF

The test is performed on a CSF sample obtained by lumbar puncture (spinal tap).

The procedure is a lumbar puncture (spinal tap). Before the procedure, you will be asked to review the risks and sign a consent form. After the lumbar puncture is done, you will be asked to remain lying down flat for 6 hours.

You will be asked to lie on your side in the fetal position with your legs curled towards your chest. The area where the needle will be inserted (in your lower back) will be thoroughly cleaned. The scrub will feel cold and wet.

You will then receive an injection at the site with local anesthesia which may sting or burn when first injected. There will be a hard pressure sensation when the needle is inserted, and there is usually some brief pain as the needle goes through. This pain should stop in a few seconds.

Usually, discomfort is mild to moderate. The entire procedure usually takes about 30 minutes but may take longer. The actual fluid collection only takes a few minutes.

The CSF-VDRL test is used to diagnose syphilis in the brain or spinal cord. Brain and spine cord involvement usually indicates a late-stage (tertiary) form of the disease. Blood screening tests, such as VDRL and RPR, are more effective during middle stage (secondary) syphilis.

Review Date: 06/10/2005
Reviewed By: Eleftherios Mylonakis, M.D., Division of Infectious Disease, Massachusetts General Hospital, Boston, MA. Review provided by VeriMed Healthcare Network.