Non-Hodgkin's Lymphoma - Outlook

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• Being male
• Being older
• Having stage III or IV disease
• Elevated levels of the enzyme lactate dehydrogenase (LDH)
• The presence of B symptoms
• Erythrocyte sedimentation rate over 30

Patients with a good chance for a positive outcome (65% chance for survival rates of 10 years or greater) have one or none of these factors; those with intermediate risk (23%) have two factors, and those likely to have a poor outcome (11%) have three or more factors. MALT lymphomas generally have a good prognosis. Primary gastric lymphomas have a 3-year survival rate of 89%.

Outlook for Aggressive (Intermediate- to High-Grade) Lymphomas

High-grade aggressive lymphomas are often symptomatic early on and are potentially curable with aggressive treatments. Diffuse large-cell lymphomas, the most common aggressive non-Hodgkin's lymphomas, while fatal if not treated, are often curable with intensive chemotherapy combinations. If relapse occurs after chemotherapy, it usually does so within 2 years.

Most other aggressive lymphomas respond to aggressive chemotherapy. Mantle cell lymphoma is less responsive to chemotherapy. The average survival time is 3 - 5 years.

Factors for Predicting Outlook in Aggressive Lymphomas: A scoring system called the International Prognostic Index has proved to be fairly accurate for predicting outcome in patients with most aggressive B-cell lymphomas. It uses five risk factors to help predict whether the disease will be aggressive:

• Being older than 60 -- this age group tends to have other medical conditions, which contribute to the poorer prognosis
• Having a disseminated tumor (stage III or IV)
• Disease that has spread to more than one site beyond the lymph nodes
• A poor performance status
• Having elevated levels of lactate dehydrogenase (LDH)

Having one or none of these risk factors indicates the best outlook; two factors indicate a low to intermediate likelihood of a poor outlook; three factors predict an intermediate to high likelihood of poor outlooks; and four or five factors pose the highest likelihood of poor survival.