Regular Exercise Helps Fight Heart Failure

By Amanda Gardner
HealthDay Reporter
Thursday, November 8, 2007; 12:00 AM

Copyright © 2007 ScoutNews, LLC. All rights reserved.

WEDNESDAY, Nov. 7 (HealthDay News) -- Exercise boosts the number of progenitor cells in people with heart failure, and those cells in turn repair and rebuild weakened muscle and blood vessels, researchers report.

According to two studies that were to be presented Wednesday at the American Heart Association annual meeting in Orlando, Fla., that response can dramatically enhance patients' ability to move and work out.

"Both studies point to the beneficial effect of exercise on patients with heart failure," said Dr. Sidney Smith, past president of the American Heart Association and director of the Center for Cardiovascular Science and Medicine at the University of North Carolina School of Medicine.

"These observations provide some understanding into the mechanisms which [make exercise helpful]," Smith said.

More than 5 million people in the United States have heart failure, a condition that affects the heart's ability to pump blood throughout the body.

However, researchers are beginning to understand that heart failure woes come not only from this pumping disorder but from changes in the legs and other parts of the body.

"The muscle of the leg starts to shrink, so there is less muscle mass," explained Dr. Axel Linke, a co-author on both studies and assistant professor of medicine at the University of Leipzig in Germany. "The endothelium and the vessels supplying blood to the muscles deteriorate, so they are less flexible, elasticity is reduced," he said. The endothelium is a layer of cells that lines blood vessels.

However, exercise opens up the vessels and improves their flexibility and elasticity.

In the first study, investigators looked at whether exercise training could activate progenitor cells -- immature cells that can divide into other cells and help repair tissue.

Fifty men with moderate-to-severe heart failure were randomized to receive either six months of exercise training under the supervision of a physician, or to be sent to a control group that remained inactive.