Gene Predicts Breast Cancer Prognosis

By Steven Reinberg
HealthDay Reporter
Thursday, April 24, 2008; 4:00 AM

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WEDNESDAY, April 23 (HealthDay News) -- A protein that stops the spread of breast cancer tumors in mice can predict which malignancies might spread, a new study suggests.

The gene, called bromodomain protein (Brd4), when added to breast cancer cells in mice, produced a unique gene signature, which was also detected in human breast cancer patients.

"We have identified that this particular gene seems to be associated with outcomes in breast cancer," said lead researcher Kent W. Hunter, a senior investigator at the U.S. National Cancer Institute. "This gene may be something we want to investigate in more detail."

Understanding how the new gene functions may lead to a better understanding of what makes breast cancer metastasize, Hunter said. "This will help identify patients who will have a better or worse outcome," he added.

The report was published in this week's issue of the Proceedings of the National Academy of Sciences.

In the study, Hunter's team inserted the gene for the Brd4 proteins into mouse breast cancer tumor cells that are known for their ability to metastasize.

However, tumor cells that contained Brd4 produced smaller tumors that did not metastasize as readily. In addition, Brd4 changed many other genes, resulting in a unique genetic signature.

The researchers then mapped the signature genes to corresponding human genes, and compared the human Brd4 signature with patient data from five large groups of breast cancer patients.

In all five groups, those patients who had the Brd4-positive signature lived longer and had a lower incidence of metastatic tumors, the researchers found. This indicates that the Brd4 gene expression signatures could accurately predict the severity of breast cancer, the researchers said.

These findings may lead to new treatments, Hunter said.

"We may not only be able to find a prognostic signature, but we can identify other genetic elements that are driving prognosis, so we may also be able to develop additional therapeutic strategies," Hunter said. "We may be able to find new drugs or strategies to improve quality of life and extend life span."