New Molecule Discovery Shows Promise Against Tamoxifen-Resistant Breast Cancers

By Amanda Gardner
HealthDay Reporter
Tuesday, June 17, 2008; 3:00 AM

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MONDAY, June 16 (HealthDay News) -- Researchers have identified a new group of compounds that might one day be added to the armamentarium of therapies designed to fight estrogen-fueled breast cancer.

"This is a potential new approach to treating hormonally sensitive tumors," said Dr. Len Lichtenfeld, deputy chief medical officer of the American Cancer Society. "If it proves to work with a lot of further research, then it does have potential as an important part of cancer research."

The study, by researchers from the University of North Carolina, Chapel Hill, the University of Colorado Health Sciences Center, Denver, and the University of Illinois, Urbana-Champaign, was presented Monday at the annual meeting of the Endocrine Society, in San Francisco.

The molecule, called TPBM, and related drugs may have a role in treating patients who have become resistant to other hormone-based therapies, such as tamoxifen.

"We have a large number of people who have estrogen receptor-positive breast cancer who respond wonderfully to hormone therapy. But, sometimes, after one or two years, the hormone therapy stops working," said Dr. Jay Brooks, chairman of hematology/oncology at Ochsner Health System in Baton Rouge, La. "[Then] we'll switch to something else. That works for about a year before the cancer progresses. So what is it that's happening in those cancer cells that they become resistant? Perhaps there is another mechanism in which we can try to keep cells in response, and this would perhaps be one of them."

Some two-thirds of all breast cancers are estrogen receptor-positive and therefore respond to hormonal treatments such as tamoxifen or the newer aromatase inhibitors.

Tamoxifen blocks estrogen receptors on breast cancer cells, while aromatase inhibitors interfere with the body's ability to produce estrogen.

But almost all cancers in this category eventually become resistant to tamoxifen and, in some cases, tamoxifen may even turn the tables and start acting like estrogen, thereby fueling tumor growth.